Genetic engineering of wild species has the potential to forever change the natural world in ways that may be irreversible. How then can we ensure these decisions are made with wisdom? In this Center for Advanced Study MillerComm Lecture, Dr. Kofler will outline how scientific and value-based knowledge can inform technology decision-making in ways that are both context-dependent and global in scope. The inadequacy of dominant theories in environmental ethics to support such decision-making will also be presented, and an alternative ethos will be proposed: one that respects the interconnectedness of human and environmental health and invites technology into that relationship to augment the flourishing of both.